the effect of topical estrogen on healing of chronic tympanic membrane perforations and hearing threshold

نویسندگان

behrouz barati departments of otolaryngology, shahid beheshti university of medical sciences, tehran, iran

seyyed hamid reza abtahi department of otorhinolaryngology, isfahan university of medical sciences, isfahan, iran

seyyed mostafa hashemi department of otorhinolaryngology, isfahan university of medical sciences, isfahan, iran

seyyed ahmad reza okhovat department of otorhinolaryngology, isfahan university of medical sciences, isfahan, iran

چکیده

normal 0 false false false en-us x-none ar-sa background: considering the presence of squamous epithelial cells and fibroblasts in the tympanic membrane (tm), topical estrogen application may influence the repair of tm perforations. therefore, this study was designed to investigate the healing effect of topical estrogen on chronic tm perforations and improvement in hearing threshold. materials and methods: sixty patients were enrolled in a randomized clinical trial. thirty patients were treated with paper patch and 30 with estrogen-impinged paper patch. complete closure of the tm perforation and hearing threshold were evaluated in both groups. chronic unilateral perforations of the tm involving less than 40% of the total area of the tm without active disease in the middle ear were selected. the margin of the perforation was chemically trimmed using 15% trichloroacetic acid and patching performed under an operating microscope. microscopic examination was performed after 14 days and repeated after 30 days. complete closure of the tm perforation was considered as successful repair. hearing threshold was determined before the start of the trial and 30 days after treatment. results: no significant difference was found between the two groups after 14 days in complete closure of the perforation ( p = 0.310). after 30 days, patients treated with estrogen-impinged paper patch showed a significantly higher rate of closure of the perforation (63.4%) and improvement in hearing threshold ( p = 0.017). conclusion: topical estrogen may have a healing effect on chronic tm perforations and improvement in hearing threshold.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The effect of topical estrogen on healing of chronic tympanic membrane perforations and hearing threshold

BACKGROUND Considering the presence of squamous epithelial cells and fibroblasts in the tympanic membrane (TM), topical estrogen application may influence the repair of TM perforations. Therefore, this study was designed to investigate the healing effect of topical estrogen on chronic TM perforations and improvement in hearing threshold. MATERIALS AND METHODS Sixty patients were enrolled in a...

متن کامل

[The effect of topical ascorbic acid application on the healing of rat tympanic membrane perforations].

OBJECTIVES We investigated the effect of topical administration of ascorbic acid on the healing process of tympanic membrane perforations in rats. DESIGN AND METHODS Thermal myringotomy was induced in both ears of 22 albino rats. The right and left ears were assigned to topical applications of ascorbic acid and saline solution, respectively. The same procedure was performed after 48 hours. Pe...

متن کامل

the effect of explicit teaching of metacognitive vocabulary learning strategies on recall and retention of idioms

چکیده ندارد.

15 صفحه اول

In response to The topical use of insulin accelerates the healing of traumatic tympanic membrane perforations.

Traumatic tympanic membrane (TM) perforations heal spontaneously ranging from 78.7% to 88%. Otologists recommend a golden rule, keep the ear dry, as an important factor influencing TM healing. This way, Araujo et al., in their article “The Topical Use of Insulin Accelerates the Healing of Traumatic Tympanic Membrane Perforations,” describe a control group of Wistar rats in which traumatic perfo...

متن کامل

In reference to The topical use of insulin accelerates the healing of traumatic tympanic membrane perforations.

OBJECTIVE In recent years, there has been a tendency to search for regulatory substances that can optimize the healing process of perforated tympanic membranes (TMs). The purpose of this study was to determine the effects of using topical insulin on the healing process of traumatic TMs perforations. STUDY DESIGN Experimental. METHODS Tympanic membranes of 20 Wistar rats were perforated in t...

متن کامل

assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.

چکیده ندارد.

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}

عنوان ژورنال:

journal of research in medical sciences

جلد ۱۸، شماره ۲، صفحات ۹۹-۰

کلمات کلیدی

[ ' e s t r o g e n ' , ' p a p e r p a t c h ' , ' p e r f o r a t i o n ' , ' t y m p a n i c m e m b r a n e r n / * s t y l e d e f i n i t i o n s * / r n t a b l e . m s o n o r m a l t a b l e r n t { m s o ' , ' s t y l e ' , ' n a m e ' , ' & ' , ' q u o t ' , ' t a b l e n o r m a l & ' , ' q u o t ' , ' m s o ' , ' t s t y l e ' , ' r o w b a n d ' , ' s i z e ' , 0 , ' m s o ' , ' t s t y l e ' , ' c o l b a n d ' , ' s i z e ' , 0 , ' m s o ' , ' s t y l e ' , ' n o s h o w ' , ' y e s ' , ' m s o ' , ' s t y l e ' , ' p r i o r i t y ' , 9 9 , ' m s o ' , ' s t y l e ' , ' q f o r m a t ' , ' y e s ' , ' m s o ' , ' s t y l e ' , ' p a r e n t ' , ' & ' , ' q u o t ' , ' & ' , ' q u o t ' , ' m s o ' , ' p a d d i n g ' , ' a l t ' , ' 0 i n 5 . 4 p t 0 i n 5 . 4 p t ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' t o p ' , ' 0 i n ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' r i g h t ' , ' 0 i n ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' b o t t o m ' , ' 1 0 . 0 p t ' , ' m s o ' , ' p a r a ' , ' m a r g i n ' , ' l e f t ' , ' 0 i n ' , ' l i n e ' , ' h e i g h t ' , ' 1 1 5 % ' , ' m s o ' , ' p a g i n a t i o n ' , ' w i d o w ' , ' o r p h a n ' , ' f o n t ' , ' s i z e ' , ' 1 1 . 0 p t ' , ' f o n t ' , ' f a m i l y ' , ' & ' , ' q u o t ' , ' c a l i b r i & ' , ' q u o t ' , ' & ' , ' q u o t ' , ' s a n s ' , ' s e r i f & ' , ' q u o t ' , ' m s o ' , ' a s c i i ' , ' f o n t ' , ' f a m i l y ' , ' c a l i b r i ' , ' m s o ' , ' a s c i i ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' l a t i n ' , ' m s o ' , ' f a r e a s t ' , ' f o n t ' , ' f a m i l y ' , ' & ' , ' q u o t ' , ' t i m e s n e w r o m a n & ' , ' q u o t ' , ' m s o ' , ' f a r e a s t ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' f a r e a s t ' , ' m s o ' , ' h a n s i ' , ' f o n t ' , ' f a m i l y ' , ' c a l i b r i ' , ' m s o ' , ' h a n s i ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' l a t i n ' , ' m s o ' , ' b i d i ' , ' f o n t ' , ' f a m i l y ' , ' a r i a l ' , ' m s o ' , ' b i d i ' , ' t h e m e ' , ' f o n t ' , ' m i n o r ' , ' b i d i ' , ' } ' ]

میزبانی شده توسط پلتفرم ابری doprax.com